HEDS is part of the School of Health and Related Research (ScHARR) at the University of Sheffield. We undertake research, teaching, training and consultancy on all aspects of health related decision science, with a particular emphasis on health economics, HTA and evidence synthesis.

Tuesday, 16 January 2018

NHS England consultations…

…on several Specialised Services clinical commissioning policies are open.  These proposals are based on a ‘rapid HTA process’ which was parly informed by work in HEDS.  The policies are:
  • Specialised Services clinical commissioning policy: Hyperbaric Oxygen Therapy for Carbon Monoxide Poisoning
  • Specialised Services clinical commissioning policy: Hyperbaric Oxygen Therapy for Decompression Illness/Gas Embolism
  • Specialised Services clinical commissioning policy: Anakinra to treat periodic fevers and autoinflammatory diseases (all ages)
  • Specialised Services clinical commissioning policy: Hyperbaric Oxygen Therapy for soft tissue radiation damage in patients with a history of pelvic irradiation for malignant disease
  • Specialised Services clinical commissioning policy: Anakinra/Tocilizumab for the treatment Adult Onset Still’s Disease refractory to second-line therapy (adults)
  • Adult Onset Still’s Disease refractory to methotrexate and corticosteroids. Related documents Anakinra/Tocilizumab... More
  • Specialised Services clinical commissioning policy: Deep Brain Stimulation for Refractory Tourette Syndrome in adults
  • Specialised Services clinical commissioning policy: Hyperbaric Oxygen Therapy for Malignant Otitis Externa
More details here

Monday, 15 January 2018

Website of the month - HTA News Portal

Yes, it’s a new feature….every month we pick out a website that we’ve found interesting.  This month it’s a new HTA news portal developed by Paul Mattheneus:

Mattheneus HTA Global HTA News Portal website


Thursday, 11 January 2018

December’s CEAs.....

Our quick search for CEA’s published in December uncovered 56 articles.   In the right-hand column of this blog is a CEA Archive, which includes our CEA search results by month.  Below are those in our areas of interest.
  • Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis. BMJ (Clinical research ed). 2017;359:j5631.
  • Dawoud D, Fenu E, Higgins B, Wonderling D, Amiel SA. Basal Insulin Regimens for Adults with Type 1 Diabetes Mellitus: A Cost-Utility Analysis. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 2017;20(10):1279-87.
  • Jendle J, Ericsson A, Hunt B, Valentine WJ, Pollock RF. Achieving Good Glycemic Control Early After Onset of Diabetes: A Cost-Effectiveness Analysis in Patients with Type 1 Diabetes in Sweden. Diabetes therapy : research, treatment and education of diabetes and related disorders. 2017.
  • Klijn SL, van den Reek J, van de Wetering G, van der Kolk A, de Jong E, Kievit W. Biologic treatment sequences for plaque psoriasis: a cost-utility analysis based on 10 years of Dutch real-world evidence from BioCAPTURE. The British journal of dermatology. 2017.

Tuesday, 9 January 2018

Job Vacancy: Research Associate/Fellow in Health Economics & Decision Modelling


HEDS are advertising for a new Research Associate/Fellow in Health Economics & Decision Modelling. 

Closing date: 07.02.2018
Post ref: UOS018118

More details about the post and the application form can be viewed here: http://bit.ly/2D7PYWM


Image of the word Jobs
CC BY 2.0 Aaaarrrrgggghhhh!



Friday, 5 January 2018

Latest Publications from HEDS in December

Our regular monthly trawl for new publications from HEDS in collaboration with colleagues in ScHARR and further afield has reaped a tremendous amount of fresh research. Many of these are currently in press, so you can find much of our work in its open access form via our institutional repository. Tuck in here.   

Image of Journal of Clinical Epidemiology Journal
© Elsevier            
       Cargo, M., Harris, J., Pantoja, T., Booth, A., Harden, A., Hannes, K., Thomas, J., Flemming, K., Garside, R., Noyes, J., 2017. Cochrane Qualitative and Implementation Methods Group Guidance Paper 3: Methods for Assessing Evidence on Intervention Implementation. Journal of Clinical Epidemiology. doi:10.1016/j.jclinepi.2017.11.028

       Carlton, J., Griffiths, H., Mazzone, P., n.d. BIOS Screening Audit report 2015-2016. doi:10.15131/shef.data.5532910

       Comans, T.A., Nguyen, K.H., Mulhern, B., Corlis, M., Li, L., Welch, A., Kurrle, S., Rowen, D.L., Moyle, W., Kularatna, S., Ratcliffe, J., n.d. Developing a dementia-specific preference-based quality of life measure (AD-5D) in Australia: Valuation study protocol. BMJ Open.

Flemming, K., Booth, A., Hannes, K., Cargo, M., Noyes, J., 2017. Cochrane Qualitative and Implementation Methods Group Guidance Paper 5: Reporting guidelines for qualitative, implementation and process evaluation evidence syntheses. Journal of Clinical Epidemiology. doi:10.1016/j.jclinepi.2017.10.022

Harden, A., Thomas, J., Cargo, M., Harris, J., Pantoja, T., Flemming, K., Booth, A., Garside, R., Hannes, K., Noyes, J., 2017. Cochrane Qualitative and Implementation Methods Group Guidance Paper 4: Methods for integrating qualitative and implementation evidence within intervention effectiveness reviews. Journal of Clinical Epidemiology. doi:10.1016/j.jclinepi.2017.11.029

Harris, J.L., Booth, A., Cargo, M., Hannes, K., Harden, A., Flemming, K., Garside, R., Pantoja, T., Thomas, J., Noyes, J., 2017. Cochrane Qualitative and Implementation Methods Group Guidance series - paper 6: Methods for question formulation, searching and protocol development for qualitative evidence synthesis. Journal of Clinical Epidemiology. doi:10.1016/j.jclinepi.2017.10.023
The Stata Journal front cover
© StataCorp

Hernandez, M., pudney, S., n.d. EQ5DMAP: a command for mapping between EQ-5D-3L and EQ-5D-5L. Stata Journal.

Latimer, N.R., White, I.R., Abrams, K.R., Sieburt, U., 2017. Causal inference for long-term survival in randomised trials with treatment switching: Should re-censoring be applied when estimating counterfactual survival times?

Martin, N.H., Ibrahim, F., Tom, B., Galloway, J., Wailoo, A., Tosh, J., Lempp, H., Prothero, L., Georgopoulou, S., Sturt, J., Scott, D.L., Jenner, R., Neatrour, I., Baggott, R., Kingsley, G., Zhong, Y., Mian, A., 2017. Does intensive management improve remission rates in patients with intermediate rheumatoid arthritis? (the TITRATE trial): Study protocol for a randomised controlled trial. Trials 18. doi:10.1186/s13063-017-2330-8

Noyes, J., Booth, A., Cargo, M., Flemming, K., Garside, R., Hannes, K., Harden, A., Harris, J., Lewin, S., Pantoja, T., Thomas, J., 2017a. Cochrane Qualitative and Implementation Methods Group Guidance Series - paper 1: Introduction. Journal of Clinical Epidemiology. doi:10.1016/j.jclinepi.2017.09.025

Noyes, J., Booth, A., Flemming, K., Garside, R., Harden, A., Lewin, S., Pantoja, T., Hannes, K., Cargo, M., Thomas, J., 2017b. Cochrane Qualitative and Implementation Methods Group Guidance paper 2: Methods for assessing methodological limitations, data extraction and synthesis, and confidence in synthesized qualitative findings. Journal of Clinical Epidemiology. doi:10.1016/j.jclinepi.2017.06.020

Picot, J., Rose, M., Cooper, K., Pickett, K., Lord, J., Harris, P., Whyte, S., Böhning, D., Shepherd, J., 2017. Virtual chromoendoscopy for the real-time assessment of colorectal polyps in vivo: a systematic review and economic evaluation. Health Technology Assessment 21, 1–308. doi:10.3310/hta21790

Image of the Emergency Medicine Journal
© BMJ
       Pollard, D., Goodacre, S., Stevenson, M., Fuller, G., 2017. 10 Decision analysis modelling of diagnostic strategies for suspected pulmonary embolism in pregnancy: the DiPEP economic evaluation., in: Emergency Medical Journal. England, pp. A867–A868. doi:10.1136/emermed-2017-207308.10

       van Hoorn, R., Tummers, M., Booth, A., Gerhardus, A., Rehfuess, E., Hind, D., Bossuyt, P.M., Welch, V., Debray, T.P.A., Underwood, M., Cuijpers, P., Kraemer, H., van der Wilt, G.J., Kievit, W., 2017. The development of CHAMP: a checklist for the appraisal of moderators and predictors. BMC Medical Research Methodology 17, 173. doi:10.1186/s12874-017-0451-0


Wailoo, A., Hock, E.S., Stevenson, M., Martyn-St James, M., Rawdin, A., Simpson, E., Wong, R., Dracup, N., Scott, D.L., Young, A., 2017. The clinical effectiveness and Cost-Effectiveness of Treat-To-Target strategies in rheumatoid arthritis: A systematic review and cost-effectiveness analysis. Health Technology Assessment. (Rockv). 21, 1–258. doi:10.3310/hta21710

Thursday, 4 January 2018

New project: NICE topics

ScHARR-TAG has been allocated the following HST topics:
  • Volanesorsen for treating familial chylomicronaemia syndrome [ID1326] (Akcea Therapeutics)
  • Patisiran for treating hereditary transthyretin-related amyloidosis [ID1279] (Alnylam Pharmaceuticals)

Tuesday, 2 January 2018

Two new free online courses from HEDS

Image of white medicine tablets
CC BY 2.0 Janels Katlaps
http://bit.ly/2zddrW2
HEDS will be running two popular FREE online courses again in 2018, so if you want to study with the experts at ScHARR to learn how difficult decisions are made about which treatments to fund, and how we can measure the value these treatments bring to patients and society, enrol now! Our Measuring and Valuing Health course is starting in February 2018 and our Health Technology Assessment course is starting in March 2018.
Click below to enrol:
Measuring and Valuing Health: https://www.futurelearn.com/courses/valuing-health
Health Technology Assessment: https://www.futurelearn.com/courses/hta

Thursday, 21 December 2017

Professor Eva Kaltenthaler receives ScHARR's Athena SWAN Award

Earlier this month HEDS Professor Eva Kaltenthaler attended the Athena SWAN Awards to accept ScHARR's second Silver Award. The event was hosted at the University of Glasgow.

Professor Kaltenthaler said: “This is a great achievement and underpins ScHARR's commitment to equality and diversity.”

Professor Eva Kaltenthaler receives ScHARR's Athena SWAN Award
Professor Eva Kaltenthaler receives ScHARR's Athena SWAN Award
The Athena SWAN Charter was established in 2005 to encourage and recognise commitment to advancing the careers of women in science, technology, engineering, maths and medicine (STEMM) employment in higher education and research.
In May 2015 the charter was expanded to recognise work undertaken in arts, humanities, social sciences, business and law (AHSSBL), and in professional and support roles, and for trans staff and students. The charter now recognises work undertaken to address gender equality more broadly, and not just barriers to progression that affect women. 

More information on the Athena SWAN Award can be seen here 

Wednesday, 20 December 2017

Happy Christmas from HEDS


Everyone at HEDS would like to wish you all a very Merry Christmas and all the best for 2018. 


Tuesday, 19 December 2017

November’s CEAs.....

Our quick search for CEA’s published in October uncovered 51 articles.   In the right-hand column of this blog is a CEA Archive, which includes our CEA search results by month.  Below are those in our areas of interest.
  • Dunning L, Francke JA, Mallampati D, MacLean RL, Penazzato M, Hou T, et al. The value of confirmatory testing in early infant HIV diagnosis programmes in South Africa: A cost-effectiveness analysis. PLoS medicine. 2017;14(11):e1002446.
  • Gordon LG, Hyland C, Hyett J, O'Brien H, Millard G, Flower R, et al. Non-invasive fetal RHD genotyping of RhD negative pregnant women for targeted anti-D therapy in Australia: a cost-effectiveness analysis. Prenatal diagnosis. 2017.
  • Hunter R, Wallace P, Struzzo P, Vedova RD, Scafuri F, Tersar C, et al. Randomised controlled non-inferiority trial of primary care-based facilitated access to an alcohol reduction website: cost-effectiveness analysis. BMJ open. 2017;7(11):e014577.
  • Lopez-Lopez JA, Sterne JAC, Thom HHZ, Higgins JPT, Hingorani AD, Okoli GN, et al. Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis. BMJ (Clinical research ed). 2017;359:j5058.
  • Padula WV, McQueen RB, Pronovost PJ. Can Economic Model Transparency Improve Provider Interpretation of Cost-effectiveness Analysis? Evaluating Tradeoffs Presented by the Second Panel on Cost-effectiveness in Health and Medicine. Medical care. 2017;55(11):909-11.